10 Best acetaminophens of 2025

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1

TIME-CAP LABS, INC.
TIME-CAP LABS, INC. Timely Acetaminophen 650 MG - 400 Caplets - Extended Release - Joint Pain Relief, Pain Reliever & Arthritis Pain Relief
Main highlights

Effective Pain Relief
Provides relief for headaches, backaches, toothaches, arthritis, and menstrual cramps.

Ideal for Family Use
400 caplets ensure long-term relief for the whole family.

Cost-Effective Solution
Praised for offering similar effectiveness to branded versions at a lower cost.
9.8

Exceptional

Our Rating

9.3
simple to consume

9.3
pain management

8.9
worth the money
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Based on millions of stores and reviews

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Analyzing top stores
Value for Money

2

Amazon Basic Care
Amazon Basic Care Acetaminophen Extended-Release Tablets, 650 mg, Arthritis Pain, 400 Count
Main highlights

Extended-Release Pain Relief
Provides 650 mg acetaminophen for up to 8-hour relief.

Ideal for Arthritis and Aches
Perfect for arthritis, backache, cramps, and other minor pains.

Value and Effectiveness
Praised for great value and effective pain relief.
9.6

Exceptional

Our Rating

9.5
simple to consume

9.5
worth the money

9.3
pain management
3

Amazon Basic Care
Amazon Basic Care Extra Strength Pain Relief, Acetaminophen Caplets, 500 mg, Pain Reliever/Fever Reducer, 500 Count (Packaging may vary)
Main highlights

Effective Pain and Fever Relief
Contains 500 mg of Acetaminophen, similar to Tylenol, for relieving minor aches and reducing fever.

Ideal for Everyday Aches
Perfect for headaches, arthritis, colds, and menstrual cramps in adults and children over 12.

Great Value for Money
Customers appreciate the cost-effectiveness and comparable performance to name brands.
9.4

Excellent

Our Rating
4

Amazon Basic Care
Amazon Basic Care Extra Strength Pain Relief, Acetaminophen Caplets, 500 mg, Pain Reliever/Fever Reducer, 100 Count (Packaging may vary)
Main highlights

Fast-Acting Pain Relief
Contains acetaminophen 500 mg for quick relief from minor aches and fever.

Versatile Use Cases
Ideal for relieving headaches, backaches, menstrual cramps, and minor arthritis pain.

Highly Praised Affordability
Customers appreciate its cost-effectiveness and performance comparable to brand-name products.
Key specs
- dosing instructions:adults and children 12+
- age suitability:12 years and over
- form:caplets
- active ingredient:acetaminophen 500 mg
- fever reduction:fever reducer
9.2

Excellent

Our Rating
5

Amazon Basic Care
Amazon Basic Care Rapid Release Acetaminophen Caplets 500 mg, Extra Strength Pain Reliever and Fever Reducer, 400 Count
Main highlights

Rapid Pain Relief and Fever Reduction
Contains 500 mg of acetaminophen for quick relief of pain and fever.

Ideal for Headaches and Muscle Aches
Perfect for headaches, muscle aches, arthritis, and menstrual pain.

Highly Praised for Effectiveness
Customers appreciate its quick and reliable pain relief.
9.0

Excellent

Our Rating
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6

Tylenol
Tylenol Extra Strength Acetaminophen Rapid Release Gels, Extra Strength Pain Reliever & Fever Reducer, Gelcaps with Laser-Drilled Holes, 500 mg Acetaminophen, 100 ct

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Main highlights

Fast Acting Relief
100-count Tylenol Extra Strength Rapid Release Gels work quickly to relieve pain and reduce fever with 500 mg acetaminophen.

Ideal for Adults and Teens
Suitable for adults and children 12 years and older, making it versatile for family use.

Highly Praised Effectiveness
Customers appreciate the fast action and effectiveness, noting the rapid relief and long-lasting results.
Key specs
- dosing instructions:Adults and children 12+
- age suitability:12 years and older
- form:Rapid release gels
- active ingredient:Acetaminophen 500mg
- fever reduction:Helps reduce fever
8.9

Very Good

Our Rating

9.7
simple to consume

9.5
worth the money

9.5
pain management
7

GoodSense
GoodSense Extra Strength Pain Relief, Acetaminophen Caplets, 500 mg, 500 Count
Main highlights

Effective Pain Relief and Fever Reduction
Contains 500 mg of Acetaminophen to relieve pain and reduce fever.

Ideal for Families and Frequent Users
Perfect for households with high demand for pain relief.

High Value for Money
Praised for large quantity and cost-effectiveness by customers.
Key specs
- dosing instructions:Adults and children 12+
- age suitability:12 years and over
- form:Caplets
- active ingredient:Acetaminophen, 500 mg
- fever reduction:Temporarily reduces fever
8.8

Very Good

Our Rating

9.9
worth the money

9.7
simple to consume

9.7
pain management
8

Tylenol
Tylenol Regular Strength Tablets with 325 mg of Acetaminophen, Fever Reducer & Pain Reliever for Headache, Backache, Muscle Aches, Joint Pain & Menstrual Cramps, 100 ct
Main highlights

Effective Pain and Fever Relief
Tylenol Regular Strength Tablets provide 325 mg of acetaminophen for temporary relief of minor aches and fever reduction.

Versatile Use for Common Ailments
Ideal for headaches, backaches, toothaches, menstrual cramps, and cold-related pain for adults and children 6 years and older.

Trusted Safety and Reliability
Praised for its reliable pain relief and safety profile, as noted in customer reviews.
Key specs
- dosing instructions:Adults and children 6+
- age suitability:6 years and older
- form:Tablets
- active ingredient:acetaminophen
- fever reduction:Yes
8.6

Very Good

Our Rating
9

TIME-CAP LABS, INC.

TIME-CAP LABS, INC. Timely Acetaminophen 325 MG Tablets 1000 Count - Regular Strength Pain Relief - Menstrual Cramps, Fever Reducer, Minor Pain of Arthritis
8.5

Good

Our Rating
10

Amazon Basic Care
Amazon Basic Care Acetaminophen Extended-Release Tablets, 650 mg, 100 Count (Packaging may vary)
Main highlights

Extended Relief Benefit
Provides up to 8 hours of pain and fever relief.

Versatile Use Cases
Ideal for minor aches, backache, arthritis, cramps, and fever.

Customer Praises Quality
Praised for being comparable to name brands in effectiveness.
8.4

Good

Our Rating

9.9
worth the money

9.7
pain management

9.3
safety

10 Best acetaminophens of 2025

1

TIME-CAP LABS, INC. Timely Acetaminophen 650 MG - 400 Caplets - Extended Release - Joint Pain Relief, Pain Reliever & Arthritis Pain Relief

9.3

9.3

8.9

How do we rank?

How do we rank?

Analyzing top stores

2

Amazon Basic Care Acetaminophen Extended-Release Tablets, 650 mg, Arthritis Pain, 400 Count

9.5

9.5

9.3

3

Amazon Basic Care Extra Strength Pain Relief, Acetaminophen Caplets, 500 mg, Pain Reliever/Fever Reducer, 500 Count (Packaging may vary)

4

Amazon Basic Care Extra Strength Pain Relief, Acetaminophen Caplets, 500 mg, Pain Reliever/Fever Reducer, 100 Count (Packaging may vary)

5

Amazon Basic Care Rapid Release Acetaminophen Caplets 500 mg, Extra Strength Pain Reliever and Fever Reducer, 400 Count

6

Tylenol Extra Strength Acetaminophen Rapid Release Gels, Extra Strength Pain Reliever & Fever Reducer, Gelcaps with Laser-Drilled Holes, 500 mg Acetaminophen, 100 ct

9.7

9.5

9.5

7

GoodSense Extra Strength Pain Relief, Acetaminophen Caplets, 500 mg, 500 Count

9.9

9.7

9.7

8

Tylenol Regular Strength Tablets with 325 mg of Acetaminophen, Fever Reducer & Pain Reliever for Headache, Backache, Muscle Aches, Joint Pain & Menstrual Cramps, 100 ct

9

TIME-CAP LABS, INC. Timely Acetaminophen 325 MG Tablets 1000 Count - Regular Strength Pain Relief - Menstrual Cramps, Fever Reducer, Minor Pain of Arthritis

10

Amazon Basic Care Acetaminophen Extended-Release Tablets, 650 mg, 100 Count (Packaging may vary)

9.9

9.7

9.3

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